Migrin
Migraine-like headaches are believed to be the result
of certain neural cells misfiring within the Brain, causing Serotonin
levels to fall, blood flow to increase and head pressure to mount. The
phytomedicinals and nutritional elements in Migrin aid in naturally
reducing the pain, inflammation and discomfort of migraine-like headaches.
The ingredients in this MiltiDimensional formula have been shown to naturally:
- Help calm and stabilize blood vessels to allow proper blood flow
- Help promote smooth neurotransmission and diminish the reactive misfirings of neurons
- Help maintain appropriate Serotonin levels within the Brain
- Help promote naturally occurring "pain-relievers" (endorphins and enkephalins)
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Order # 632 - Migrin $19.95
Migrin is a Scientific Formulation of Natural Ingredients Including:
DL-Phenylalanine (DLPA): Acts
via PEA mechanisms to regulate Serotonin production and utilization,
thus inhibiting the "spreading depression" model of migraines;
nutritionally inhibits the production of enzymes which defeat naturally
occurring "pain-relievers"
(endorphins and enkephalins), aiding the reduction of pain and inflammation.
L-Glutamic Acid & L-Glutamine: Amino acids that act both as inhibitory and excitatory neurotransmitters, resupplying deficiencies in neurons and supporting glial cells, shutting down the inhibitory systems of GABA so that the smooth muscles in veins and arteries don't overdialate.
White Willow Bark: Thought to inhibit the neural transfer of pain signals. Contains the natural pharmaceutically active compound salicin, or salicylic acid, the chemical forerunner of acetylsalicylic acid (modern aspirin), known to complement the body's ability to relieve discomfort but without the possible complications caused by aspirin.
Tanacetum Parthenium (Feverfew): Used since ancient times for severe headaches and migraines, recent research has revealed its antiinflammatory properties, allowing a stabilization of cerebral blood vessels by counteracting those substances that permit excessive blood flow which enlarges the arteries.
L-Taurine & L-Glycine: Amino acids with natural calming properties, acting as major inhibitory neurotransmitters of the brain and found useful in soothing the uncontrolled agitation and reactive misfiring of neurons.
Iris Versicolor: known to work upon the nervous system, and is used for migraine and cluster headaches as yet another antidialator.
Specifically Targeted Micro-Nutritionals, Free Form Amino Acids & More: Provides electromagnetic instructions to further support the body's abilities to address inflammation and pain.
Studies show that electrical stimulation within the mid-brain, in the area of the dorsal raphe neurons (specific neural cells which have the highest concentration of Serotonin receptors and subsequently alter cerebral blood flow), can result in the cascading activity of falling Serotonin levels, which increases blood flow and results in migraine-like headaches. Thus, headaches may be diminished naturally by inhibiting the firing of these neurons
This Scientifically Advanced Neurological Nutraceutical formula is a Dietary Supplement with the specific nutrients of key amino acids and supporting phytomedicinals that aid the body in regulating serotonin utilization and shutting down inhibitory systems while not increasing blood flow, all of which act to provide relief from pain. It is a safe and non-addictive formulation which will not interfere with other medications but act to enhance their respective potency, as well as acting as a safe non-addicting mild mood elevator. When taken regularly, this dietary formula acts as a nutritional "fortifier" providing the body with the means to help itself against further attacks of severe headache, as well as to help reduce the overall frequency.
Historically, an understanding of migraines has evolved from that of a "vascular" model to one which more correctly is a type of "spreading cortical" phenomenon of 3 phases.
It was widely held for many years that the headache phase of migrainous attacks was caused by extracranial vasodilatation and that neurologic symptoms were produced by intracranial vasoconstriction, the "vascular" hypothesis of migraine. A barrage of publications followed in support of this hypothesis so that differing observations were sadly ignored. However, observations made over the past decade have finally rendered untenable the "vascular" hypothesis and lend support to what is known as a "spreading depression" model.
(Please note that this is not a state of psychological depression, but rather "depressed" or diminished cortical activity.) Despite the fact that this model has some 50 years of history, it was vigorously resisted because it could not possibly be incorporated into the "vascular" model of migraine, which had previously been tenaciously grasped by the medical community.
Now, the "spreading depression" model has found more acceptance, and is described as a slowly moving (2- to 3-mm/min) potassium-liberating "depression" of cortical activity, preceded by a wavefront of increased metabolic activity that can be produced by a variety of experimental stimuli, including hypoxia, mechanical trauma, and the topical application of potassium.
The pathogenesis of migraine as it is currently understood can be partitioned into three phases:
- Brain (stem) generation;
- vasomotor activation wherein arteries both within and outside the brain may contract or dilate;
- Activation of cells of the medullary trigeminal nucleus caudalis (the brain's head and face pain-processing mechanism) and the subsequent release of vasoactive neuropeptides at vascular terminations of the trigeminal nerve.
This last phase provides a reasonable mechanism for the soft-tissue swelling and tenderness of blood vessels that attend migraine attacks. It seems clear that activation of any of the phases is sufficient for headache production, and that perhaps any one phase may appear to dominate in a particular migrainous syndrome.
Electrical stimulation within the mid-brain near the area of the dorsal raphe neurons, can result in migraine like headaches. There are projections from the dorsal raphe that terminate on cerebral arteries and alter cerebral blood flow. There are also major projections from the dorsal raphe to important visual processing way stations, including the lateral geniculate body, superior colliculus, retina, and visual cortex.
Now, it appears that platelet levels of Serotonin fall consistently at the onset of headache and that migrainous episodes may be triggered by drugs that release Serotonin. The highest concentration of serotonin receptors exist within the mid-brain dorsal raphe area. When overstimulation of these neurons occur, an overabundance of Serotonin is realeased, over relaxing neurons and causing them to misfire which causes blood flow to increase and enlarge arteries, leading to common migraine symptoms such as head and eye pain.
The dorsal raphe cells stop firing during deep sleep, and sleep is known to ameliorate migraine; the antimigraine drugs also stop the firing of the dorsal raphe cells through a direct or indirect agonist effect. The shutdown of an inhibitory system might be expected to enhance or stabilize neurotransmission, and there is evidence that this indeed occurs. Migraine may represent, therefore, a hereditary perturbation of serotonergic neurotransmission. Such perturbation may underlie many types of head pain; ordinary periodic headaches may be the "noise" of the normally functioning system.
Specifically, Vaxa Migrin complements the body nutritively by ensuring an abundant supply of biochemical precursors, such as DLPA (DL-Phenylalanine), which acts, via PEA mechanisms, to regulate serotonin production and utilization, thus inhibiting the mechanism of migraine modeled after the "spreading depression."
L-Glutamic acid, and its uncharged amide, L-Glutamine, act as inhibitory neurotransmitters, being taken up by the all important glial cells. The glial cells (or glia) are the supporting, non-neuronal cells of the central nervous system (CNS). They are as important as the neurons, which could not function without them. They wrap around and enclose the axons, dendrites, synapses and blood vessels. They probably control the composition of the interstitial medium. There are about ten times more glial cells than neurons in the CNS.
After Glutamic acid uptake via the glial cells, Glutamine is quickly converted to Glutamic acid, and then diffused into the neurons, resupplying glutamine deficiencies. Glutamic acid as an excitatory neurotransmitter, balancing the possibility of inhibitory overload (shutting down the inhibitory systems of GABA) so that the smooth muscles of vascular groups do not become too relaxed, and thus add to the severity of migraine and cluster headaches. L-Asparagine is a neutral amino acid necessary for secretory calcium-binding protein activity; the presence of Ca2+ ions are mandatory and regulatory within the central nervous system.
Migrin has been developed especially for those requiring nutritional support when under a physician's care and experiencing migraine headaches and related problems. Migraine and frontal headaches are often violent, severe and incapacitating, with often accompanying reoccurring shooting pains through the temples, and with accompanying constipation, nausea, fainting, vomiting and irritability, blurring of sight, hallucinations, obscuration of sight, neuralgia and twitching of limbs, pains running from the neck into the head made worse by sudden movement, increased tactile and photo-sensitivity.